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Research Study Summaries

This page gives details of all the research projects Park Surgery has recruited for over the years and those still actively recruiting.  As research findings and their implications are made available by the study teams they will be added here, so if you've been involved in a particular study you can check back here later on to see updated information regarding 'your' study.  Studies are listed alphabetically by acronym.


This study aimed to find out what symptoms, measurements and characteristics can be used to predict which patients with a cough and suspected lower respiratory tract infection (LRTI) go on to develop complications, i.e. pneumonia severe enough to require hospitalisation. Over 30,000 patients in total were recruited from across the country.

Study completed enrolment in Spring 2013.


The aim of the study is to find out the most effective treatment for chronic hand eczema, and will compare the drug Alitretinoin with the usual treatment of UVA phototherapy/drug treatment with Psoralen. It is recruiting at East Surrey Hospital (ESH), Redhill. GP practices are supporting recruitment by displaying copies of the study poster (so patients can contact the study team directly). In addition to displaying posters, patients with severe hand eczema can be referred to ESH.

For further information please click here

Recruitment ongoing.

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BARRIERS TO UPTAKE OF INTRAUTERINE CONTRACEPTION

Intrauterine contraception (IUC) is safe, long-lasting and highly effective.  Despite this, there is a low level of usage for contraception and this study was designed to investigate barriers for patients and clinicians.  Patients reported fears about the risk of the method and dislike of a device in the womb.  The long-acting nature of the method also made it unattractive to some users.  For practitioners, organisational barriers were reported as presenting a challenge in terms of practice premises, staff time and training to fit.  Recommendations:  Better and more relevent information about IUC which addresses the concerns of users is required for patients. Increased levels of training among those not trained to fit could increase recommendations of IUC as a suitable contraception method.  Improved access to training for clinicians in also needed to increase pool of fitters and make IUC more easily available in General Practice.

For further information please click here

Recruitment complete

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This study seeks to work out which of the symptoms and examination findings are the most effective in predicting lung or colon cancer. It aims to recruit a total of 20 000 patients who consult their GP - half with lung symptoms and the other half with low bowel symptoms.

Projected benefits:

  • Earlier diagnosis and treatment
  • Less investigation of low risk patients
  • More efficient use of both primary and secondary care resources

For further information please click here

Recruiting until September 2017

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Caring for Carers

c4c

This Study aims to establish whether Positive Written Disclosure (PWD – a type of writing therapy) improves the wellbeing of caregivers of people with psychosis.

Further information can be found here http://www.sussex.ac.uk/spriglab/research/current/caringforcarers

Recruitment complete.

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Child-Parent Screening Study: Familial Hypercholesterolaemia

This study looked at the feasibility of screening for familial hypercholesterolaemia (FH), an inherited condition that affects around 1 to 2 in every 250 people in the UK. It can cause abnormally high cholesterol levels. It doesn't usually cause any noticeable symptoms, but people with FH aged between 20 and 40 are 100 times more likely to have a heart attack than other people their age.

UK researchers tested 10,095 one-year-olds to explore the feasibility of screening for FH. They tested the toddlers at the same time they had routine vaccinations at the age of one. Researchers found 28 children with FH. The parents of children with FH were then also tested. The study found not all children with an FH mutation had high cholesterol, however, and some with high cholesterol did not have a known FH mutation. This means FH mutation testing alone would not be a useful screening test, so the researchers suggest testing cholesterol levels first. The approach used in the study does have the added benefit of identifying parents with FH who didn't realise the condition ran in their family. Once FH is diagnosed, it is relatively straightforward to treat through making lifestyle changes and taking drugs known to reduce cholesterol, mainly statins. This research will help inform the UK's National Screening Committee when considering whether the benefits of screening for FH outweigh the harms.

See BBC news article at http://www.bbc.co.uk/news/health-37775310

And NHS Choices website summary of the study at http://www.nhs.uk/news/2016/10October/Pages/Study-advises-screening-toddlers-for-heart-disease-risk.aspx

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CONTACT - Low dose colchicine or naproxen treatment for acute gout

Gout is the most prevalent inflammatory arthritis. It is largely managed in primary care but with varying treatment regimens. Treatment is most frequently with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or oral colchicine. Oral colchicine has been used to treat acute gout for many years although high-doses can cause intolerable gastrointestinal side-effects. Low-dose colchicine is thought to be as effective and better-tolerated and is now recommended. This study primarily aims to compare the effectiveness of low-dose colchicine and naproxen for reducing pain in adults consulting their GP with acute gout. The trial will also look at side-effects, cost-effectiveness, adherence to treatment and time taken to reduce pain.

Recruitment complete.

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FLUENZ

Safety surveillance of the influenza vaccine (QLAIV) fluenz tetra in children and adolescents during the early 2015/2016 influenza season in England. Practices took part by giving information to patients during the flu season.

Recruitment complete.

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GARFIELD

The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF Registry) is a pioneering real-world prospective registry - one of the largest in the field of non-valvular atrial fibrillation (AF). With an enrolment of 57,262 patients, GARFIELD-AF aims to enhance understanding of stroke prevention in patients with non-valvular AF worldwide and help in defining future treatment strategies that may eventually influence patient outcomes.

For further information, see http://af.garfieldregistry.org/

Recruitment complete.

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GETTING DOWN TO COPING - Online self-management after treatment for prostate cancer: a feasibility study

The study represents a four week, online, self-management intervention for men experiencing distress related to disease and treatment side-effects of prostate cancer. A film called Getting Down to Coping®was made to be shown to participants in a self-management programme which is being tested by the University of Surrey team in a randomised controlled trial. The programme teaches men practical, physical and cognitive ways to help them cope with the urinary symptoms they experience after radiotherapy treatment for prostate cancer. Seven men speak candidly and helpfully in the film about their personal stories and coping realities.

To view the video, please see <ahref="http://www.surrey.ac.uk/mediacentre/press/2012/76405_new_video_launched_to_help_prostate_cancer_patients.htm">http://www.surrey.ac.uk/mediacentre/press/2012/76405_new_video_launched_to_help_prostate_cancer_patients.htm

Recruitment complete.

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HEAT

H. pylori are spiral-shaped bacteria that grow in the digestive tract and have a
tendency to attack the stomach lining.  The HEAT trial aims to find out whether eradication of H.pylori will prevent ulcer bleeding, in patients taking low-dose aspirin. Participants attend one screening clinic at the practice and H.pylori-positive patients receive one week’s worth of eradication medication or matched placebo.

http://nuhrise.org/2012/08/heat-helicobacter-eradication-aspirin-trial-can-a-one-week-course-of-eradication-reduce-hospitalisation/

Recruitment ongoing.

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PRIMIT

The PRIMIT study covers the development and clinical trial of a website designed to reduce transmission of cold and flu viruses in households. The website can be used during normal seasonal flu and in the event of pandemic flu.

The website has four weekly sessions which encourage users to plan and learn how to use simple techniques to avoid catching and passing on viruses. Findings from the pilot phase showed highly significant increases for both intention to perform and the actual behaviour of the main technique, at both the one and three month follow-ups. Recruitment complete.

Results to date: 16,908 participants were followed up. The intervention reduced transmission of respiratory tract infections both to and from the index person.

Conclusions: In non-pandemic years an effective internet intervention designed to increase hand-washing could have an important impact in reducing infection transmission. Paper published in Lancet.

See http://www.southampton.ac.uk/namrip/research/behaviour-in-the-wider-world/primit.page

Recruitment complete.

 

Questionnaire for staff - developing and validating a new self-report measure of compassion

Researchers at Sussex Partnership NHS Foundation Trust and the University of Sussex are working on a project to develop a new questionnaire measure of compassion. To develop the measure, they need to collect data from 1,300 NHS staff working in a Trust or GP practice in the Kent, Surrey, and Sussex region, in a role that involves at least one day per week of direct patient contact.  Participation will involve completing an anonymous, online survey.

Recruitment ongoing.

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Safety Monitoring of Flu Vaccination 2017/2018

Surveillance of Side-Effects from this year’s Seasonal Influenza Vaccine – Patients were asked to report any suspected adverse reactions following routine flu vaccination as part of the monitoring carried out at GP practices annually by the company supplying the vaccine.  Report cards were given out to Park patients vaccinated early in the season and they were asked to call a Freephone number to report as necessary.  Rates of side effects being reported will be compared with those reported last year.   The aim of this data collection is to rapidly identify and evaluate any potential new safety concern each influenza season to mitigate risks before the peak period of seasonal immunisation. 

Recruitment complete.

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SNIFS

This study looked at methods of treating chronic sinus infections

The study recruited patients with recurrent or chronic sinusitis and patients were randomised to one of the following four treatment options:

  1. nasal irrigation
  2. steam inhalation
  3. a combination of both
  4. or normal treatment

Results to date: No effect of steam; Irrigation helped:10 point clinically important improvement. 44.1% irrigation vs. 36.6% no irrigation; Fewer patients used over-the-counter medication (59% vs. 68%); Patient confidence improved around self-management of condition.

Conclusions: Advice to use steam inhalation for chronic or recurrent sinus symptoms in primary care was not effective. A similar strategy to use nasal irrigation was less effective than prior evidence suggested, but it provided some symptomatic benefit.

See http://www.southampton.ac.uk/news/2016/07/steam-inhalation.page

Recruitment complete.

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StartRight - Getting the right classification and treatment from diagnosis of Diabetes

A leading diabetes consultant at Surrey and Sussex Healthcare NHS Trust (Dr. Benjamin Field) and his team are studying patients who have been recently diagnosed with diabetes to find out whether early testing of blood samples can help to improve diabetes treatment. Recruitment is restricted to patients aged 18-50 who have been diagnosed within the previous 12 months. This study aims to achieve more accurate early classification of diabetes and identification of which patients will rapidly require insulin treatment.

Recruitment ongoing.

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STILTS 2

This is an observational study which aims to recruit a substantial cohort of thin people (2000) to identify genes that contribute to thinness and may provide further insights into the regulation of body weight and obesity resistance. This may inform rational preventative and therapeutic strategies for weight disorders.

Recruitment complete.

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TIME

The study aims to find out if antihypertensive therapy taken in the evening has improved cardiovascular outcomes compared with more conventional morning dosing. Patients took part by signing up online.

See www.TimeStudy.co.uk

Recruitment complete.

VACCept Survey Study

This study aims to find out what women know about Human Papillomavirus (HPV) and what they feel about HPV vaccination.  If you are between 30-45 years old and attending the surgery for a routine smear, you may be asked to participate.  Despite cervical smear testing, cervical cancer still affects a significant number of women.  High-risk HPV viruses cause nearly all cervical cancer and vaccines are available which work best if given prior to any sexual activity.  In the UK, girls aged 12-13 can be vaccinated in school.  Older women cannot get the vaccine on the NHS.  Some countries offer the vaccine to older women as it may protect if the woman is not already been exposed.  However, not all women offered the vaccine choose to have it and reasons around this choice may enable the set-up of a clinical trial offering HPV vaccination to women attending for cervical screening in the UK.

Recruiting until January 2019.

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